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Evolutionary and molecular foundations of multiple contemporary functions of the nitroreductase superfamily

Insight regarding how diverse enzymatic functions and reactions have evolved from ancestral scaffolds is fundamental to understanding chemical and evolutionary biology, and for the exploitation of enzymes for biotechnology. We undertook an extensive computational analysis using a unique and comprehe...

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Detalles Bibliográficos
Autores principales: Akiva, Eyal, Copp, Janine N., Tokuriki, Nobuhiko, Babbitt, Patricia C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692541/
https://www.ncbi.nlm.nih.gov/pubmed/29078300
http://dx.doi.org/10.1073/pnas.1706849114