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A minimally sufficient model for rib proximal-distal patterning based on genetic analysis and agent-based simulations

For decades, the mechanism of skeletal patterning along a proximal-distal axis has been an area of intense inquiry. Here, we examine the development of the ribs, simple structures that in most terrestrial vertebrates consist of two skeletal elements—a proximal bone and a distal cartilage portion. Wh...

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Detalles Bibliográficos
Autores principales: Fogel, Jennifer L, Lakeland, Daniel L, Mah, In Kyoung, Mariani, Francesca V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693115/
https://www.ncbi.nlm.nih.gov/pubmed/29068314
http://dx.doi.org/10.7554/eLife.29144