Crystallizable Fragment Glycoengineering for Therapeutic Antibodies Development

Monoclonal antibody (mAb)-based therapeutics are the fastest growing class of human pharmaceuticals. They are typically IgG1 molecules with N-glycans attached to the N297 residue on crystallizable fragment (Fc). Different Fc glycoforms impact their effector function, pharmacokinetics, stability, agg...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Wei, Zhu, Zhongyu, Chen, Weizao, Feng, Yang, Dimitrov, Dimiter S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693878/
https://www.ncbi.nlm.nih.gov/pubmed/29181010
http://dx.doi.org/10.3389/fimmu.2017.01554

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693878/
https://www.ncbi.nlm.nih.gov/pubmed/29181010
http://dx.doi.org/10.3389/fimmu.2017.01554

Ejemplares similares