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Engineered Soluble Monomeric IgG1 Fc with Significantly Decreased Non-Specific Binding
Due to the long serum half-life provided by the neonatal Fc receptor (FcRn) recycling, the IgG1 Fc has been pursued as the fusion partner to develop therapeutic Fc-fusion proteins, or as the antibody-derived scaffold that could be engineered with antigen-binding capabilities. In previous studies, we...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693891/ https://www.ncbi.nlm.nih.gov/pubmed/29181008 http://dx.doi.org/10.3389/fimmu.2017.01545 |