Transcriptional signature of human pro-inflammatory T(H)17 cells identifies reduced IL10 gene expression in multiple sclerosis

We have previously reported the molecular signature of murine pathogenic T(H)17 cells that induce experimental autoimmune encephalomyelitis (EAE) in animals. Here we show that human peripheral blood IFN-γ(+)IL-17(+) (T(H)1/17) and IFN-γ(−)IL-17(+) (T(H)17) CD4(+) T cells display distinct transcripti...

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Detalles Bibliográficos
Autores principales: Hu, Dan, Notarbartolo, Samuele, Croonenborghs, Tom, Patel, Bonny, Cialic, Ron, Yang, Tun-Hsiang, Aschenbrenner, Dominik, Andersson, Karin M., Gattorno, Marco, Pham, Minh, Kivisakk, Pia, Pierre, Isabelle V., Lee, Youjin, Kiani, Karun, Bokarewa, Maria, Tjon, Emily, Pochet, Nathalie, Sallusto, Federica, Kuchroo, Vijay K., Weiner, Howard L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693957/
https://www.ncbi.nlm.nih.gov/pubmed/29150604
http://dx.doi.org/10.1038/s41467-017-01571-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693957/
https://www.ncbi.nlm.nih.gov/pubmed/29150604
http://dx.doi.org/10.1038/s41467-017-01571-8

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