TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells

Plasmacytoid dendritic cells (pDC) sense viral RNA through toll-like receptor 7 (TLR7), form self-adhesive pDC–pDC clusters, and produce type I interferons. This cell adhesion enhances type I interferon production, but little is known about the underlying mechanisms. Here we show that MyD88-dependen...

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Detalles Bibliográficos
Autores principales: Saitoh, Shin-Ichiroh, Abe, Fumiko, Kanno, Atsuo, Tanimura, Natsuko, Mori Saitoh, Yoshiko, Fukui, Ryutaro, Shibata, Takuma, Sato, Katsuaki, Ichinohe, Takeshi, Hayashi, Mayumi, Kubota, Kazuishi, Kozuka-Hata, Hiroko, Oyama, Masaaki, Kikko, Yorifumi, Katada, Toshiaki, Kontani, Kenji, Miyake, Kensuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693993/
https://www.ncbi.nlm.nih.gov/pubmed/29150602
http://dx.doi.org/10.1038/s41467-017-01687-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693993/
https://www.ncbi.nlm.nih.gov/pubmed/29150602
http://dx.doi.org/10.1038/s41467-017-01687-x

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