Cargando…

Ketamine’s antidepressant effect is mediated by energy metabolism and antioxidant defense system

Fewer than 50% of all patients with major depressive disorder (MDD) treated with currently available antidepressants (ADs) show full remission. Moreover, about one third of the patients suffering from MDD does not respond to conventional ADs and develop treatment-resistant depression (TRD). Ketamine...

Descripción completa

Detalles Bibliográficos
Autores principales:	Weckmann, Katja, Deery, Michael J., Howard, Julie A., Feret, Renata, Asara, John M., Dethloff, Frederik, Filiou, Michaela D., Iannace, Jamie, Labermaier, Christiana, Maccarrone, Giuseppina, Webhofer, Christian, Teplytska, Larysa, Lilley, Kathryn, Müller, Marianne B., Turck, Christoph W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694011/ https://www.ncbi.nlm.nih.gov/pubmed/29150633 http://dx.doi.org/10.1038/s41598-017-16183-x

Ejemplares similares

Time-dependent metabolomic profiling of Ketamine drug action reveals hippocampal pathway alterations and biomarker candidates
por: Weckmann, K, et al.
Publicado: (2014)

Behavioral and Metabolome Differences between C57BL/6 and DBA/2 Mouse Strains: Implications for Their Use as Models for Depression- and Anxiety-Like Phenotypes
por: Filiou, Michaela D., et al.
Publicado: (2021)

Purine and pyrimidine metabolism: Convergent evidence on chronic antidepressant treatment response in mice and humans
por: Park, Dong Ik, et al.
Publicado: (2016)

Multi-Omics Analysis Reveals Myelin, Presynaptic and Nicotinate Alterations in the Hippocampus of G72/G30 Transgenic Mice
por: Filiou, Michaela D., et al.
Publicado: (2022)

Delineation of molecular pathway activities of the chronic antidepressant treatment response suggests important roles for glutamatergic and ubiquitin–proteasome systems
por: Park, D I, et al.
Publicado: (2017)

Biomarkers Predicting Antidepressant Treatment Response: How Can We Advance the Field?
por: Labermaier, Christiana, et al.
Publicado: (2013)

Metabolite profiling of antidepressant drug action reveals novel drug targets beyond monoamine elevation
por: Webhofer, C, et al.
Publicado: (2011)

Ketamine: stimulating antidepressant treatment?
por: Malhi, Gin S., et al.
Publicado: (2016)

Immunoregulation and antidepressant effect of ketamine
por: Zhang, Nan, et al.
Publicado: (2021)

Lipid metabolism is associated with temperament, corticosteroid, and hematological measures in infant rhesus monkeys (Macaca mulatta)
por: Capitanio, John P., et al.
Publicado: (2020)

The Ketamine Antidepressant Story: New Insights
por: Alshammari, Tahani K.
Publicado: (2020)

The role of dissociation in ketamine’s antidepressant effects
por: Ballard, Elizabeth D., et al.
Publicado: (2020)

The antidepressant properties of ketamine (literature review)
por: Chamsi, F. Z., et al.
Publicado: (2023)

Antidepressant effects of ketamine: mechanisms underlying fast-acting novel antidepressants
por: Browne, Caroline A., et al.
Publicado: (2013)

Stable Isotope Metabolic Labeling with a Novel (15)N-Enriched Bacteria Diet for Improved Proteomic Analyses of Mouse Models for Psychopathologies
por: Frank, Elisabeth, et al.
Publicado: (2009)

Proteomic Differences in Blood Plasma Associated with Antidepressant Treatment Response
por: Turck, Christoph W., et al.
Publicado: (2017)

FKBP5 Gene Expression Predicts Antidepressant Treatment Outcome in Depression
por: Ising, Marcus, et al.
Publicado: (2019)

Ketamine as Antidepressant? Current State and Future Perspectives
por: Hasselmann, H. W.W.
Publicado: (2014)

Is Metabolism of (R)-Ketamine Essential for the Antidepressant Effects?
por: Chaki, Shigeyuki
Publicado: (2017)

Structural Integrity in the Sustained Antidepressant Effect of Ketamine
por: Belujon, Pauline
Publicado: (2017)

Ketamine: a new chapter in antidepressant development
por: Zarate, Carlos A.
Publicado: (2020)

Activation of σ1-Receptors by R-Ketamine May Enhance the Antidepressant Effect of S-Ketamine
por: Kalkman, Hans O.
Publicado: (2023)

Rapid Antidepressant Response with Ketamine: Is it the Solution to Resistant Depression?
por: Thakurta, Rajarshi Guha, et al.
Publicado: (2012)

Acute Antidepressant Effects of Intramuscular Versus Intravenous Ketamine
por: Chilukuri, Harihar, et al.
Publicado: (2014)

Antidepressant mechanism of ketamine: perspective from preclinical studies
por: Scheuing, Lisa, et al.
Publicado: (2015)

NMDAR inhibition-independent antidepressant actions of ketamine metabolites
por: Zanos, Panos, et al.
Publicado: (2016)

Beyond Ketamine: New Approaches to the Development of Safer Antidepressants
por: Chaki, Shigeyuki
Publicado: (2017)

The Antidepressant Effect of Ketamine Is Dampened by Concomitant Benzodiazepine Medication
por: Andrashko, Veronika, et al.
Publicado: (2020)

Uncovering the Underlying Mechanisms of Ketamine as a Novel Antidepressant
por: Xu, Songbai, et al.
Publicado: (2022)

Plasma fibrinogen: now also an antidepressant response marker?
por: Martins-de-Souza, D, et al.
Publicado: (2014)

Studying pre-treatment and ketamine-induced changes in white matter microstructure in the context of ketamine’s antidepressant effects
por: Sydnor, Valerie J., et al.
Publicado: (2020)

Acute Antidepressant Effects of Intramuscular Versus Intravenous Ketamine: Erratum
Publicado: (2015)

The positive effect on ketamine as a priming adjuvant in antidepressant treatment
por: Melo, A, et al.
Publicado: (2015)

Hippocampal Perineuronal Nets Are Required for the Sustained Antidepressant Effect of Ketamine
por: Donegan, Jennifer J, et al.
Publicado: (2016)

Does the Opioid System Block or Enhance the Antidepressant Effects of Ketamine?
por: Mathew, Sanjay J., et al.
Publicado: (2019)

Molecular and Cellular Mechanisms of Rapid-Acting Antidepressants Ketamine and Scopolamine
por: Wohleb, Eric S., et al.
Publicado: (2017)

Hydroxynorketamine: Implications for the NMDA Receptor Hypothesis of Ketamine’s Antidepressant Action
por: Aleksandrova, Lily R., et al.
Publicado: (2017)

Opioid Properties of Nitrous Oxide and Ketamine Contribute to Their Antidepressant Actions
por: Gillman, Mark A
Publicado: (2021)

Th17 Cells in Depression: Are They Crucial for the Antidepressant Effect of Ketamine?
por: Cui, Meiying, et al.
Publicado: (2021)

Ketamine Alters Functional Plasticity of Astroglia: An Implication for Antidepressant Effect
por: Stenovec, Matjaž
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_mcceshdar7uadtn65viqdahual