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Antibody Heavy Chain Variable Domains of Different Germline Gene Origins Diversify through Different Paths
B cells produce antibodies, key effector molecules in health and disease. They mature their properties, including their affinity for antigen, through hypermutation events; processes that involve, e.g., base substitution, codon insertion and deletion, often in association with an isotype switch. Inve...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694033/ https://www.ncbi.nlm.nih.gov/pubmed/29180996 http://dx.doi.org/10.3389/fimmu.2017.01433 |