Cargando…

Pharmacokinetics of a New Oral Vitamin D Receptor Activator (2-Methylene-19-Nor-(20S)-1α,25-Dihydroxyvitamin D(3)) in Patients with Chronic Kidney Disease and Secondary Hyperparathyroidism on Hemodialysis

BACKGROUND: 2-Methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D(3) (DP001 or 2MD) is a novel, potent 1α-hydroxylated vitamin D analog that binds to the vitamin D receptor and suppresses parathyroid hormone synthesis and secretion with potential for an improved safety profile compared to existing activ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pandey, Richa, Zella, Julia B., Zhu, Jinge G., Plum, Lori A., Clagett-Dame, Margaret, Blaser, William J., Bedale, Wendy, DeLuca, Hector F., Coyne, Daniel W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2017
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694423/ https://www.ncbi.nlm.nih.gov/pubmed/28905271 http://dx.doi.org/10.1007/s40268-017-0210-z

Ejemplares similares

Antibody production in mice requires neither vitamin D, nor the vitamin D receptor
por: Plum, Lori A., et al.
Publicado: (2022)

Differential activity of 2-methylene-19-nor vitamin D analogs on growth factor gene expression in rhino mouse skin and comparison to all-trans retinoic acid
por: Ahrens, Jamie M., et al.
Publicado: (2017)

MON-388 Total and Free 1,25dihydroxyvitamin D Levels in Postmenopausal Patients with Primary Hyperparathyroidism
por: Meng, Lingqiong, et al.
Publicado: (2020)

Suppressive Effect of 19-nor-1α-25-Dihydroxyvitamin D2 on Gastric Cancer Cells and Peritoneal Metastasis Model
por: Park, Mi Ra, et al.
Publicado: (2012)

1,25-Dihydroxyvitamin D and the Vitamin D Receptor Gene Polymorphism Apa1 Influence Bone Mineral Density in Primary Hyperparathyroidism
por: Christensen, Monika H. E., et al.
Publicado: (2013)

Vitamin D binding protein greatly improves bioactivity but is not essential for orally administered vitamin D
por: Duchow, Elizabeth G., et al.
Publicado: (2021)

Vitamin D is not required for adaptive immunity to listeria
por: Baisa, Gary A., et al.
Publicado: (2019)

Gene expression profiles in rat intestine identify pathways for 1,25-dihydroxyvitamin D(3) stimulated calcium absorption and clarify its immunomodulatory properties
por: Kutuzova, Galina D., et al.
Publicado: (2004)

Primary Human Osteoblasts in Response to 25-Hydroxyvitamin D(3), 1,25-Dihydroxyvitamin D(3) and 24R,25-Dihydroxyvitamin D(3)
por: van der Meijden, Karen, et al.
Publicado: (2014)

Vitamin D deficiency in the Apc(Pirc/+) rat does not exacerbate colonic tumorigenesis, while low dietary calcium might be protective
por: Irving, Amy A., et al.
Publicado: (2018)

Vitamin D receptor absence does not enhance intestinal tumorigenesis in Apc(Pirc/+)rats
por: Irving, Amy A., et al.
Publicado: (2022)

The relationship of 1,25-dihydroxyvitamin D and Vitamin D binding protein in periodontitis
por: Rafique, Sara, et al.
Publicado: (2019)

1α,25-Dihydroxyvitamin D(3) (calcitriol) and its analogue, 19-nor-1α,25(OH)(2)D(2), potentiate the effects of ionising radiation on human prostate cancer cells
por: Dunlap, N, et al.
Publicado: (2003)

THU233 Reduction Of Overutilization Of 1,25-Dihydroxyvitamin D
por: Brown, Jeremy, et al.
Publicado: (2023)

Vitamin A in Reproduction and Development
por: Clagett-Dame, Margaret, et al.
Publicado: (2011)

Impact of Race on Hyperparathyroidism, Mineral Disarrays, Administered Vitamin D Mimetic, and Survival in Hemodialysis Patients
por: Kalantar-Zadeh, Kamyar, et al.
Publicado: (2010)

Managing hyperparathyroidism in hemodialysis: role of etelcalcetide
por: Eidman, Keith E, et al.
Publicado: (2018)

A complex RARE is required for the majority of Nedd9 embryonic expression
por: Knutson, Danielle C., et al.
Publicado: (2014)

Serum 1,25-Dihydroxyvitamin D: An Outcome Prognosticator in Human Sepsis
por: Nguyen, H. Bryant, et al.
Publicado: (2013)

Expression of nephronectin is enhanced by 1α,25‐dihydroxyvitamin D(3)
por: Hiranuma, Katsuhiro, et al.
Publicado: (2016)

Focus on 1,25-Dihydroxyvitamin D3 in the Peripheral Nervous System
por: Faye, Pierre Antoine, et al.
Publicado: (2019)

The Use of 1α,25-Dihydroxyvitamin D(3) as an Anticancer Agent
por: Marcinkowska, Ewa, et al.
Publicado: (2016)

Familial vitamin D resistant rickets: End-organ resistance to 1,25-dihydroxyvitamin D
por: Choudhury, Sangita, et al.
Publicado: (2013)

Kidney disease and vitamin D levels: 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, and VDR activation
por: Dusso, Adriana S
Publicado: (2011)

Strategies for the Synthesis of 19-nor-Vitamin D Analogs
por: Fernández, Susana, et al.
Publicado: (2020)

Vitamin D, 1,25-Dihydroxyvitamin D, FGF23, and Graft Function after Renal Transplantation
por: Mehrotra, Sonia, et al.
Publicado: (2019)

25-Hydroxyvitamin D, 1,25-Dihydroxyvitamin D, and Peripheral Bone Densitometry in Adults with Celiac Disease
por: Ciacci, Carolina, et al.
Publicado: (2020)

Characteristics of Serum Ratios of 1,25-Dihydroxyvitamin D to 25-Hydroxyvitamin D for Assessment of Bone Metabolism
por: Yamamoto, Koichiro, et al.
Publicado: (2021)

Hemodialysis patients’ preferences for the management of secondary hyperparathyroidism
por: Hauber, Brett, et al.
Publicado: (2017)

Attenuation of constitutive DNA damage signaling by 1,25-dihydroxyvitamin D3
por: Halicka, H. Dorota, et al.
Publicado: (2012)

Mechanistic study of the cause of decreased blood 1,25-Dihydroxyvitamin D in sepsis
por: Li, Chih-Huang, et al.
Publicado: (2019)

Association of Vitamin D and secondary hyperparathyroidism with anemia in diabetic kidney disease
por: Sonkar, Satyendra Kumar, et al.
Publicado: (2018)

Vitamin D Binding Protein and Monocyte Response to 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D: Analysis by Mathematical Modeling
por: Chun, Rene F., et al.
Publicado: (2012)

Vitamin D Status and Indices of Mineral Homeostasis in the Population: Differences Between 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D
por: Cirillo, Massimo, et al.
Publicado: (2019)

8-Cl-Adenosine enhances 1,25-dihydroxyvitamin D(3)-induced growth inhibition without affecting 1,25-dihydroxyvitamin D(3)-stimulated differentiation of primary mouse epidermal keratinocytes
por: Bollag, Wendy B, et al.
Publicado: (2004)

The effect of 1,25-dihydroxyvitamin D3 on lymphoma cell lines and expression of vitamin D receptor in lymphoma.
por: Hickish, T., et al.
Publicado: (1993)

25-Hydroxyvitamin D(3) and 1,25-Dihydroxyvitamin D(3) Promote the Differentiation of Human Subcutaneous Preadipocytes
por: Nimitphong, Hataikarn, et al.
Publicado: (2012)

Vitamin D deficiency increases vulnerability to canagliflozin-induced adverse effects on 1,25-dihydroxyvitamin D and PTH
por: Yazdi, Zhinous Shahidzadeh, et al.
Publicado: (2023)

The influence of BsmI and TaqI vitamin D receptor gene polymorphisms on the intensity of hyperparathyroidism in Iranian hemodialysis patients
por: Pourfarzam, Morteza, et al.
Publicado: (2014)

1, 25-dihydroxyvitamin D3 decreases adriamycin-induced podocyte apoptosis and loss
por: Zou, Min-shu, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_rji38tljv4umoo8aet80djvgcr