A Randomized Multiple Dose Pharmacokinetic Study of a Novel PDE10A Inhibitor TAK-063 in Subjects with Stable Schizophrenia and Japanese Subjects and Modeling of Exposure Relationships to Adverse Events

BACKGROUND: Phosphodiesterase 10A (PDE10A) is selectively expressed in medium spiny neurons of the striatum. TAK-063 is a selective inhibitor of PDE10A in clinical development for the treatment of schizophrenia. OBJECTIVES: Safety, tolerability, and pharmacokinetics (PK) of TAK-063 were evaluated fo...

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Detalles Bibliográficos
Autores principales: Goldsmith, Paul, Affinito, John, McCue, Maggie, Tsai, Max, Roepcke, Stefan, Xie, Jinhui, Gertsik, Lev, Macek, Thomas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2017
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694427/
https://www.ncbi.nlm.nih.gov/pubmed/29103081
http://dx.doi.org/10.1007/s40268-017-0214-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694427/
https://www.ncbi.nlm.nih.gov/pubmed/29103081
http://dx.doi.org/10.1007/s40268-017-0214-8

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