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Age-related pacemaker deterioration is due to impaired intracellular and membrane mechanisms: Insights from numerical modeling
Age-related deterioration of pacemaker function has been documented in mammals, including humans. In aged isolated sinoatrial node tissues and cells, reduction in the spontaneous action potential (AP) firing rate was associated with deterioration of intracellular and membrane mechanisms; however, th...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Rockefeller University Press
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694941/ https://www.ncbi.nlm.nih.gov/pubmed/28887411 http://dx.doi.org/10.1085/jgp.201711792 |