In-Tether Chiral Center Induced Helical Peptide Modulators Target p53-MDM2/MDMX and Inhibit Tumor Growth in Stem-Like Cancer Cell

Inhibition of the interaction between p53 and MDM2/MDMX has attracted significant attention in anticancer therapy development. We designed a series of in-tether chiral center-induced helical stabilized peptides, among which MeR/PhR effectively reactivated p53. The activation of p53 inhibits cell pro...

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Detalles Bibliográficos
Autores principales: Hu, Kuan, Yin, Feng, Yu, Mengyin, Sun, Chengjie, Li, Jingxu, Liang, Yujie, Li, Wenjun, Xie, Mingsheng, Lao, Yuanzhi, Liang, Wei, Li, Zi-gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695149/
https://www.ncbi.nlm.nih.gov/pubmed/29158845
http://dx.doi.org/10.7150/thno.19840

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695149/
https://www.ncbi.nlm.nih.gov/pubmed/29158845
http://dx.doi.org/10.7150/thno.19840

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