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Genome-guided identification of novel head-to-tail cyclized antimicrobial peptides, exemplified by the discovery of pumilarin

The need for novel antibiotics in an era where antimicrobial resistance is on the rise, and the number of new approved antimicrobial drugs reaching the market is declining, is evident. The underused potential of post-translationally modified peptides for clinical use makes this class of peptides int...

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Detalles Bibliográficos
Autores principales: van Heel, Auke J., Montalban-Lopez, Manuel, Oliveau, Quentin, Kuipers, Oscar P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695211/
https://www.ncbi.nlm.nih.gov/pubmed/29177092
http://dx.doi.org/10.1099/mgen.0.000134