Profiling RNA-Seq at multiple resolutions markedly increases the number of causal eQTLs in autoimmune disease

Genome-wide association studies have identified hundreds of risk loci for autoimmune disease, yet only a minority (~25%) share genetic effects with changes to gene expression (eQTLs) in immune cells. RNA-Seq based quantification at whole-gene resolution, where abundance is estimated by culminating e...

Descripción completa

Detalles Bibliográficos
Autores principales: Odhams, Christopher A., Cunninghame Graham, Deborah S., Vyse, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695635/
https://www.ncbi.nlm.nih.gov/pubmed/29059182
http://dx.doi.org/10.1371/journal.pgen.1007071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695635/
https://www.ncbi.nlm.nih.gov/pubmed/29059182
http://dx.doi.org/10.1371/journal.pgen.1007071

Ejemplares similares