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Profiling RNA-Seq at multiple resolutions markedly increases the number of causal eQTLs in autoimmune disease
Genome-wide association studies have identified hundreds of risk loci for autoimmune disease, yet only a minority (~25%) share genetic effects with changes to gene expression (eQTLs) in immune cells. RNA-Seq based quantification at whole-gene resolution, where abundance is estimated by culminating e...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695635/ https://www.ncbi.nlm.nih.gov/pubmed/29059182 http://dx.doi.org/10.1371/journal.pgen.1007071 |