Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo

Retinoic acid receptor-related-orphan-receptor-C (RORγt) is the key transcription factor that is driving the differentiation of IL-17 producing T-helper 17 (Th17) cells that are implicated in the pathology of various autoimmune and inflammatory diseases. Based on the importance of RORγt in promoting...

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Detalles Bibliográficos
Autores principales: Guendisch, Ulf, Weiss, Jessica, Ecoeur, Florence, Riker, Julia Christina, Kaupmann, Klemens, Kallen, Joerg, Hintermann, Samuel, Orain, David, Dawson, Janet, Billich, Andreas, Guntermann, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695821/
https://www.ncbi.nlm.nih.gov/pubmed/29155882
http://dx.doi.org/10.1371/journal.pone.0188391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695821/
https://www.ncbi.nlm.nih.gov/pubmed/29155882
http://dx.doi.org/10.1371/journal.pone.0188391

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