A mobile loop near the active site acts as a switch between the dual activities of a viral protease/deubiquitinase

The positive-strand RNA virus Turnip yellow mosaic virus (TYMV) encodes an ovarian tumor (OTU)-like protease/deubiquitinase (PRO/DUB) protein domain involved both in proteolytic processing of the viral polyprotein through its PRO activity, and in removal of ubiquitin chains from ubiquitylated substr...

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Detalles Bibliográficos
Autores principales: Jupin, Isabelle, Ayach, Maya, Jomat, Lucile, Fieulaine, Sonia, Bressanelli, Stéphane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695851/
https://www.ncbi.nlm.nih.gov/pubmed/29117247
http://dx.doi.org/10.1371/journal.ppat.1006714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695851/
https://www.ncbi.nlm.nih.gov/pubmed/29117247
http://dx.doi.org/10.1371/journal.ppat.1006714

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