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PTEN Regulates Glucose Transporter Recycling by Impairing SNX27 Retromer Assembly
The tumor suppressor PTEN executes cellular functions predominantly through its phosphatase activity. Here we identified a phosphatase-independent role for PTEN during vesicular trafficking of the glucose transporter GLUT1. PTEN physically interacts with SNX27, a component of the retromer complex th...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695913/ https://www.ncbi.nlm.nih.gov/pubmed/29117568 http://dx.doi.org/10.1016/j.celrep.2017.10.053 |