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The exon 38-containing ARHGEF11 splice isoform is differentially expressed and is required for migration and growth in invasive breast cancer cells

Breast cancer invasion involves the loss of cell-cell junctions and acquisition of an invasive, migratory phenotype, and breast cancer cells of the basal intrinsic subtype are more invasive and metastatic than breast cancer cells of other subtypes. ARHGEF11 is a RhoGEF that was previously shown to b...

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Detalles Bibliográficos
Autores principales: Itoh, Masahiko, Radisky, Derek C., Hashiguchi, Masaaki, Sugimoto, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696171/
https://www.ncbi.nlm.nih.gov/pubmed/29190905
http://dx.doi.org/10.18632/oncotarget.20985