Noninvasive liquid diet delivery of stable isotopes into mouse models for deep metabolic network tracing

Delivering isotopic tracers for metabolic studies in rodents without overt stress is challenging. Current methods achieve low label enrichment in proteins and lipids. Here, we report noninvasive introduction of (13)C(6)-glucose via a stress-free, ad libitum liquid diet. Using NMR and ion chromatogra...

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Detalles Bibliográficos
Autores principales: Sun, Ramon C., Fan, Teresa W.-M., Deng, Pan, Higashi, Richard M., Lane, Andrew N., Le, Anh-Thu, Scott, Timothy L., Sun, Qiushi, Warmoes, Marc O., Yang, Ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696342/
https://www.ncbi.nlm.nih.gov/pubmed/29158483
http://dx.doi.org/10.1038/s41467-017-01518-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696342/
https://www.ncbi.nlm.nih.gov/pubmed/29158483
http://dx.doi.org/10.1038/s41467-017-01518-z

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