Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC

Botulinum neurotoxins (BoNTs), the most potent toxins known, are potential bioterrorism agents. It is well established that all seven serotypes of BoNTs (BoNT/A–G) require complex gangliosides as co-receptors. Here, we report that BoNT/DC, a presumed mosaic toxin between BoNT/D and BoNT/C1, binds an...

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Detalles Bibliográficos
Autores principales: Zhang, Sicai, Berntsson, Ronnie P.-A., Tepp, William H., Tao, Liang, Johnson, Eric A., Stenmark, Pål, Dong, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696347/
https://www.ncbi.nlm.nih.gov/pubmed/29158482
http://dx.doi.org/10.1038/s41467-017-01534-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696347/
https://www.ncbi.nlm.nih.gov/pubmed/29158482
http://dx.doi.org/10.1038/s41467-017-01534-z

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