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Highly expressed genes evolve under strong epistasis from a proteome-wide scan in E. coli
Epistasis or the non-additivity of mutational effects is a major force in protein evolution, but it has not been systematically quantified at the level of a proteome. Here, we estimated the extent of epistasis for 2,382 genes in E. coli using several hundreds of orthologs for each gene within the cl...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696520/ https://www.ncbi.nlm.nih.gov/pubmed/29158562 http://dx.doi.org/10.1038/s41598-017-16030-z |