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Highly expressed genes evolve under strong epistasis from a proteome-wide scan in E. coli

Epistasis or the non-additivity of mutational effects is a major force in protein evolution, but it has not been systematically quantified at the level of a proteome. Here, we estimated the extent of epistasis for 2,382 genes in E. coli using several hundreds of orthologs for each gene within the cl...

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Detalles Bibliográficos
Autores principales: Dasmeh, Pouria, Girard, Éric, Serohijos, Adrian W. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696520/
https://www.ncbi.nlm.nih.gov/pubmed/29158562
http://dx.doi.org/10.1038/s41598-017-16030-z

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