Attenuation of the Infiltration of Angiotensin II Expressing CD3(+) T-Cells and the Modulation of Nerve Growth Factor in Lumbar Dorsal Root Ganglia – A Possible Mechanism Underpinning Analgesia Produced by EMA300, An Angiotensin II Type 2 (AT(2)) Receptor Antagonist

Recent preclinical and proof-of-concept clinical studies have shown promising analgesic efficacy of selective small molecule angiotensin II type 2 (AT(2)) receptor antagonists in the alleviation of peripheral neuropathic pain. However, their cellular and molecular mechanism of action requires furthe...

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Detalles Bibliográficos
Autores principales: Khan, Nemat, Muralidharan, Arjun, Smith, Maree T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696600/
https://www.ncbi.nlm.nih.gov/pubmed/29200998
http://dx.doi.org/10.3389/fnmol.2017.00389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696600/
https://www.ncbi.nlm.nih.gov/pubmed/29200998
http://dx.doi.org/10.3389/fnmol.2017.00389

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