Targeting the Hemopexin-like Domain of Latent Matrix Metalloproteinase-9 (proMMP-9) with a Small Molecule Inhibitor Prevents the Formation of Focal Adhesion Junctions

[Image: see text] A lack of target specificity has greatly hindered the success of inhibitor development against matrix metalloproteinases (MMPs) for the treatment of various cancers. The MMP catalytic domains are highly conserved, whereas the hemopexin-like domains of MMPs are unique to each family...

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Detalles Bibliográficos
Autores principales: Alford, Vincent M., Kamath, Anushree, Ren, Xiaodong, Kumar, Kunal, Gan, Qianwen, Awwa, Monaf, Tong, Michael, Seeliger, Markus A., Cao, Jian, Ojima, Iwao, Sampson, Nicole S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697452/
https://www.ncbi.nlm.nih.gov/pubmed/28945333
http://dx.doi.org/10.1021/acschembio.7b00758

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697452/
https://www.ncbi.nlm.nih.gov/pubmed/28945333
http://dx.doi.org/10.1021/acschembio.7b00758

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