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Targeting the Hemopexin-like Domain of Latent Matrix Metalloproteinase-9 (proMMP-9) with a Small Molecule Inhibitor Prevents the Formation of Focal Adhesion Junctions
[Image: see text] A lack of target specificity has greatly hindered the success of inhibitor development against matrix metalloproteinases (MMPs) for the treatment of various cancers. The MMP catalytic domains are highly conserved, whereas the hemopexin-like domains of MMPs are unique to each family...
Autores principales: | Alford, Vincent M., Kamath, Anushree, Ren, Xiaodong, Kumar, Kunal, Gan, Qianwen, Awwa, Monaf, Tong, Michael, Seeliger, Markus A., Cao, Jian, Ojima, Iwao, Sampson, Nicole S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American
Chemical
Society
2017
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697452/ https://www.ncbi.nlm.nih.gov/pubmed/28945333 http://dx.doi.org/10.1021/acschembio.7b00758 |
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