Direct arterial injection of hyperpolarized (13)C‐labeled substrates into rat tumors for rapid MR detection of metabolism with minimal substrate dilution

PURPOSE: A rat model was developed to enable direct administration of hyperpolarized (13)C‐labeled molecules into a tumor‐supplying artery for magnetic resonance spectroscopy (MRS) studies of tumor metabolism. METHODS: Rat P22 sarcomas were implanted into the right inguinal fat pad of BDIX rats such...

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Detalles Bibliográficos
Autores principales: Reynolds, Steven, Metcalf, Stephen, Cochrane, Edward J., Collins, Rebecca C., Jones, Simon, Paley, Martyn N.J., Tozer, Gillian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Full Papers—Preclinical and Clinical Spectroscopy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697693/
https://www.ncbi.nlm.nih.gov/pubmed/28191664
http://dx.doi.org/10.1002/mrm.26628

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697693/
https://www.ncbi.nlm.nih.gov/pubmed/28191664
http://dx.doi.org/10.1002/mrm.26628

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