The A946T variant IFIH1 RNA sensor mediates an interferon program that limits viral infection but increases the risk for autoimmunity

The single nucleotide polymorphism, rs1990760, in the cytosolic viral sensor, IFIH1, results in an amino-acid change (p.A946T) and is associated with multiple autoimmune diseases. The impact of this polymorphism on both viral-sensing and autoimmune pathogenesis remains poorly understood. Here, we fi...

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Detalles Bibliográficos
Autores principales: Gorman, Jacquelyn A., Hundhausen, Christian, Errett, John S., Stone, Amy E., Allenspach, Eric J., Ge, Yan, Arkatkar, Tanvi, Clough, Courtnee, Dai, Xuezhi, Khim, Socheath, Pestal, Kathleen, Liggitt, Denny, Cerosaletti, Karen, Stetson, Daniel B., James, Richard G., Oukka, Mohamed, Concannon, Patrick, Gale, Michael, Buckner, Jane H., Rawlings, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697900/
https://www.ncbi.nlm.nih.gov/pubmed/28553952
http://dx.doi.org/10.1038/ni.3766

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697900/
https://www.ncbi.nlm.nih.gov/pubmed/28553952
http://dx.doi.org/10.1038/ni.3766

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