Genetically tunable frustration controls allostery in an intrinsically disordered transcription factor

Intrinsically disordered proteins (IDPs) present a functional paradox because they lack stable tertiary structure, but nonetheless play a central role in signaling, utilizing a process known as allostery. Historically, allostery in structured proteins has been interpreted in terms of propagated stru...

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Detalles Bibliográficos
Autores principales: Li, Jing, White, Jordan T, Saavedra, Harry, Wrabl, James O, Motlagh, Hesam N, Liu, Kaixian, Sowers, James, Schroer, Trina A, Thompson, E Brad, Hilser, Vincent J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697930/
https://www.ncbi.nlm.nih.gov/pubmed/29022880
http://dx.doi.org/10.7554/eLife.30688

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697930/
https://www.ncbi.nlm.nih.gov/pubmed/29022880
http://dx.doi.org/10.7554/eLife.30688

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