Cargando…

Genetically tunable frustration controls allostery in an intrinsically disordered transcription factor

Intrinsically disordered proteins (IDPs) present a functional paradox because they lack stable tertiary structure, but nonetheless play a central role in signaling, utilizing a process known as allostery. Historically, allostery in structured proteins has been interpreted in terms of propagated stru...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Jing, White, Jordan T, Saavedra, Harry, Wrabl, James O, Motlagh, Hesam N, Liu, Kaixian, Sowers, James, Schroer, Trina A, Thompson, E Brad, Hilser, Vincent J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697930/ https://www.ncbi.nlm.nih.gov/pubmed/29022880 http://dx.doi.org/10.7554/eLife.30688

Ejemplares similares

Correction: Genetically tunable frustration controls allostery in an intrinsically disordered transcription factor
por: Li, Jing, et al.
Publicado: (2018)

Dynamic allostery can drive cold adaptation in enzymes
por: Saavedra, Harry G., et al.
Publicado: (2018)

Dynamic allostery in substrate binding by human thymidylate synthase
por: Bonin, Jeffrey P, et al.
Publicado: (2022)

Recruitment of two dyneins to an mRNA-dependent Bicaudal D transport complex
por: Sladewski, Thomas E, et al.
Publicado: (2018)

Multivalency regulates activity in an intrinsically disordered transcription factor
por: Clark, Sarah, et al.
Publicado: (2018)

Multivalency regulates activity in an intrinsically disordered transcription factor
por: Clark, Sarah, et al.
Publicado: (2018)

Fine-tuning of intrinsic N-Oct-3 POU domain allostery by regulatory DNA targets
por: Alazard, Robert, et al.
Publicado: (2007)

Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A
por: Olivieri, Cristina, et al.
Publicado: (2020)

Autoinhibition of ankyrin-B/G membrane target bindings by intrinsically disordered segments from the tail regions
por: Chen, Keyu, et al.
Publicado: (2017)

Intrinsic Flexibility of Ubiquitin on Proliferating Cell Nuclear Antigen (PCNA) in Translesion Synthesis
por: Hibbert, Richard G., et al.
Publicado: (2012)

Emergence and evolution of an interaction between intrinsically disordered proteins
por: Hultqvist, Greta, et al.
Publicado: (2017)

High temperature sensitivity is intrinsic to voltage-gated potassium channels
por: Yang, Fan, et al.
Publicado: (2014)

Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs
por: Lin, Yuan, et al.
Publicado: (2017)

Dissection of the interaction between the intrinsically disordered YAP protein and the transcription factor TEAD
por: Mesrouze, Yannick, et al.
Publicado: (2017)

Different Ligands of the TRPV3 Cation Channel Cause Distinct Conformational Changes as Revealed by Intrinsic Tryptophan Fluorescence Quenching
por: Billen, Bert, et al.
Publicado: (2015)

Folding and binding pathways of BH3-only proteins are encoded within their intrinsically disordered sequence, not templated by partner proteins
por: Crabtree, Michael D., et al.
Publicado: (2018)

Simple biophysics underpins collective conformations of the intrinsically disordered proteins of the Nuclear Pore Complex
por: Vovk, Andrei, et al.
Publicado: (2016)

Synergy and allostery in ligand binding by HIV-1 Nef
por: Aldehaiman, Abdullah, et al.
Publicado: (2021)

Structural Characterization of Hsp12, the Heat Shock Protein from Saccharomyces cerevisiae, in Aqueous Solution Where It Is Intrinsically Disordered and in Detergent Micelles Where It Is Locally α-Helical
por: Singarapu, Kiran K., et al.
Publicado: (2011)

Work minimization accounts for footfall phasing in slow quadrupedal gaits
por: Usherwood, James R, et al.
Publicado: (2017)

Molecular structures of the eukaryotic retinal importer ABCA4
por: Liu, Fangyu, et al.
Publicado: (2021)

An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering
por: Keedy, Daniel A, et al.
Publicado: (2018)

Molecular basis for N-terminal alpha-synuclein acetylation by human NatB
por: Deng, Sunbin, et al.
Publicado: (2020)

Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis
por: Ramakrishnan, Sathish, et al.
Publicado: (2020)

Inhibition of the proton-activated chloride channel PAC by PIP(2)
por: Mihaljević, Ljubica, et al.
Publicado: (2023)

Top-down machine learning approach for high-throughput single-molecule analysis
por: White, David S, et al.
Publicado: (2020)

ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling
por: Hou, Panpan, et al.
Publicado: (2019)

Mechanistic insights into the active site and allosteric communication pathways in human nonmuscle myosin-2C
por: Chinthalapudi, Krishna, et al.
Publicado: (2017)

Resting mitochondrial complex I from Drosophila melanogaster adopts a helix-locked state
por: Padavannil, Abhilash, et al.
Publicado: (2023)

Investigating Homology between Proteins using Energetic Profiles
por: Wrabl, James O., et al.
Publicado: (2010)

Ligand binding remodels protein side-chain conformational heterogeneity
por: Wankowicz, Stephanie A, et al.
Publicado: (2022)

Molecular mechanism underlying desensitization of the proton-activated chloride channel PAC
por: Osei-Owusu, James, et al.
Publicado: (2022)

Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21
por: Dickson, Claire, et al.
Publicado: (2018)

Fidaxomicin jams Mycobacterium tuberculosis RNA polymerase motions needed for initiation via RbpA contacts
por: Boyaci, Hande, et al.
Publicado: (2018)

Structural basis of ribosomal peptide macrocyclization in plants
por: Haywood, Joel, et al.
Publicado: (2018)

Bipolar filaments of human nonmuscle myosin 2-A and 2-B have distinct motile and mechanical properties
por: Melli, Luca, et al.
Publicado: (2018)

Structural basis for transcription complex disruption by the Mfd translocase
por: Kang, Jin Young, et al.
Publicado: (2021)

PIE-scope, integrated cryo-correlative light and FIB/SEM microscopy
por: Gorelick, Sergey, et al.
Publicado: (2019)

A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription
por: Sdano, Matthew A, et al.
Publicado: (2017)

Rift Valley fever phlebovirus NSs protein core domain structure suggests molecular basis for nuclear filaments
por: Barski, Michal, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_bomfge5kem2v7d7ao9haqellrv