Crystal structures reveal an elusive functional domain of pyrrolysyl-tRNA synthetase

Pyrrolysyl-tRNA synthetase (PylRS) is a major tool in genetic code expansion with non-canonical amino acids, yet understanding of its structure and activity is incomplete. Here we describe the crystal structure of the previously uncharacterized essential N-terminal domain of this unique enzyme in co...

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Detalles Bibliográficos
Autores principales: Suzuki, Tateki, Miller, Corwin, Guo, Li-Tao, Ho, Joanne M. L., Bryson, David I., Wang, Yane-Shih, Liu, David R., Söll, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698177/
https://www.ncbi.nlm.nih.gov/pubmed/29035363
http://dx.doi.org/10.1038/nchembio.2497

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698177/
https://www.ncbi.nlm.nih.gov/pubmed/29035363
http://dx.doi.org/10.1038/nchembio.2497

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