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Crystal structures reveal an elusive functional domain of pyrrolysyl-tRNA synthetase
Pyrrolysyl-tRNA synthetase (PylRS) is a major tool in genetic code expansion with non-canonical amino acids, yet understanding of its structure and activity is incomplete. Here we describe the crystal structure of the previously uncharacterized essential N-terminal domain of this unique enzyme in co...
Autores principales: | Suzuki, Tateki, Miller, Corwin, Guo, Li-Tao, Ho, Joanne M. L., Bryson, David I., Wang, Yane-Shih, Liu, David R., Söll, Dieter |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698177/ https://www.ncbi.nlm.nih.gov/pubmed/29035363 http://dx.doi.org/10.1038/nchembio.2497 |
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