Intrinsic short-tailed azole resistance in mucormycetes is due to an evolutionary conserved aminoacid substitution of the lanosterol 14α-demethylase

Mucormycoses are emerging and potentially lethal infections. An increase of breakthrough infections has been found in cohorts receiving short-tailed azoles prophylaxis (e.g. voriconazole (VCZ)). Although VCZ is ineffective in vitro and in vivo, long-tailed triazoles such as posaconazole remain activ...

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Detalles Bibliográficos
Autores principales: Caramalho, Rita, Tyndall, Joel D. A., Monk, Brian C., Larentis, Thomas, Lass-Flörl, Cornelia, Lackner, Michaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698289/
https://www.ncbi.nlm.nih.gov/pubmed/29162893
http://dx.doi.org/10.1038/s41598-017-16123-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698289/
https://www.ncbi.nlm.nih.gov/pubmed/29162893
http://dx.doi.org/10.1038/s41598-017-16123-9

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