The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia

Cytarabine (AraC) represents the most effective single agent treatment for AML. Nevertheless, overriding AraC resistance in AML remains an unmet medical need. Here we show that the CHK1 inhibitor (CHK1i) GDC-0575 enhances AraC-mediated killing of AML cells both in vitro and in vivo, thus abrogating...

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Detalles Bibliográficos
Autores principales: Di Tullio, Alessandro, Rouault-Pierre, Kevin, Abarrategi, Ander, Mian, Syed, Grey, William, Gribben, John, Stewart, Aengus, Blackwood, Elizabeth, Bonnet, Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698422/
https://www.ncbi.nlm.nih.gov/pubmed/29162833
http://dx.doi.org/10.1038/s41467-017-01834-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698422/
https://www.ncbi.nlm.nih.gov/pubmed/29162833
http://dx.doi.org/10.1038/s41467-017-01834-4

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