Cargando…

Novel p53 therapies for head and neck cancer

Inactivation of the tumor suppressor p53 is the predominant pathogenetic event in head and neck squamous cell carcinoma (HNSCC). The p53 pathway in HNSCC can be compromised through multiple mechanisms including gene mutations, hyperactivation of endogenous negative p53 regulators and by the human pa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Castellanos, Mario R., Pan, Quintin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	KeAi Publishing 2016
Materias:	Novel discoveries/Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698513/ https://www.ncbi.nlm.nih.gov/pubmed/29204550 http://dx.doi.org/10.1016/j.wjorl.2016.05.005

Ejemplares similares

The current status of oncolytic viral therapy for head and neck cancer
por: Old, Matthew O., et al.
Publicado: (2016)

Intra-tumor heterogeneity in head and neck cancer and its clinical implications
por: Mroz, Edmund A., et al.
Publicado: (2016)

mTOR, metabolism, and the immune response in HPV-positive head and neck squamous cell cancer
por: Coppock, Joseph D., et al.
Publicado: (2016)

Interleukin-6 role in head and neck squamous cell carcinoma progression
por: Choudhary, Moaz M., et al.
Publicado: (2016)

The Elephant Evolved p53 Isoforms that Escape MDM2-Mediated Repression and Cancer
por: Padariya, Monikaben, et al.
Publicado: (2022)

CD10 as a novel marker of therapeutic resistance and cancer stem cells in head and neck squamous cell carcinoma
por: Fukusumi, T, et al.
Publicado: (2014)

p53-dependent and p53-independent anticancer effects of different histone deacetylase inhibitors
por: Sonnemann, J, et al.
Publicado: (2014)

p53 mutation, deprivation and poor prognosis in primary breast cancer
por: Baker, L, et al.
Publicado: (2010)

Inhibitor of DNA binding 2 is a novel therapeutic target for stemness of head and neck squamous cell carcinoma
por: Bae, Woo Jin, et al.
Publicado: (2017)

Molecular disruption of NBS1 with targeted gene delivery enhances chemosensitisation in head and neck cancer
por: Araki, K, et al.
Publicado: (2010)

Dual Functions of labial Resolve the Hox Logic of Chelicerate Head Segments
por: Gainett, Guilherme, et al.
Publicado: (2023)

Sequence-dependent effects of ZD1839 (‘Iressa’) in combination with cytotoxic treatment in human head and neck cancer
por: Magné, N, et al.
Publicado: (2002)

Interferon-alpha enhances the antitumour activity of EGFR-targeted therapies by upregulating RIG-I in head and neck squamous cell carcinoma
por: Ma, Hailong, et al.
Publicado: (2018)

Species Persistence with Hybridization in Toad-Headed Lizards Driven by Divergent Selection and Low Recombination
por: Gao, Wei, et al.
Publicado: (2022)

Combined effects of bevacizumab with erlotinib and irradiation: a preclinical study on a head and neck cancer orthotopic model
por: Bozec, A, et al.
Publicado: (2008)

Ancient Human Genomes and Environmental DNA from the Cement Attaching 2,000-Year-Old Head Lice Nits
por: Pedersen, Mikkel W, et al.
Publicado: (2021)

Variation in Pleiotropic Hub Gene Expression Is Associated with Interspecific Differences in Head Shape and Eye Size in Drosophila
por: Buchberger, Elisa, et al.
Publicado: (2021)

Potential role of p53 on metallothionein induction in human epithelial breast cancer cells
por: Fan, L Z, et al.
Publicado: (2002)

Doxorubicin and vinorelbine act independently via p53 expression and p38 activation respectively in breast cancer cell lines
por: Liem, A A, et al.
Publicado: (2003)

p28, A first in class peptide inhibitor of cop1 binding to p53
por: Yamada, T, et al.
Publicado: (2013)

Dual inhibition of EGFR and VEGFR pathways in combination with irradiation: antitumour supra-additive effects on human head and neck cancer xenografts
por: Bozec, A, et al.
Publicado: (2007)

SKLB188 inhibits the growth of head and neck squamous cell carcinoma by suppressing EGFR signalling
por: Barzegar, Mansoureh, et al.
Publicado: (2017)

MR‐based CT metal artifact reduction for head‐and‐neck photon, electron, and proton radiotherapy
por: Nielsen, Jonathan Scharff, et al.
Publicado: (2019)

Differential response of head and neck cancer cell lines to TRAIL or Smac mimetics is associated with the cellular levels and activity of caspase-8 and caspase-10
por: Raulf, N, et al.
Publicado: (2014)

The dual PI3K/mTOR inhibitor PKI-587 enhances sensitivity to cetuximab in EGFR-resistant human head and neck cancer models
por: D'Amato, V, et al.
Publicado: (2014)

Targeted radiosensitisation by pegylated liposome-encapsulated 3′, 5′-O-dipalmitoyl 5-iodo-2′-deoxyuridine in a head and neck cancer xenograft model
por: Harrington, K J, et al.
Publicado: (2004)

Oestrogen inhibits resveratrol-induced post-translational modification of p53 and apoptosis in breast cancer cells
por: Zhang, S, et al.
Publicado: (2004)

Combined treatment of the experimental human papilloma virus-16-positive cervical and head and neck cancers with cisplatin and radioimmunotherapy targeting viral E6 oncoprotein
por: Harris, M, et al.
Publicado: (2013)

Cisplatin alters nitric oxide synthase levels in human ovarian cancer cells: involvement in p53 regulation and cisplatin resistance
por: Leung, E L, et al.
Publicado: (2008)

A TRiP to the plasma membrane
por: Ghosh, Debapriya, et al.
Publicado: (2015)

p53 protein regulates the effects of amifostine on apoptosis, cell cycle progression, and cytoprotection
por: Lee, E J, et al.
Publicado: (2003)

The Role of p53 and MDM2 in Head and Neck Cancer
por: Denaro, N., et al.
Publicado: (2011)

Repositioning Fenofibrate to Reactivate p53 and Reprogram the Tumor-Immune Microenvironment in HPV+ Head and Neck Squamous Cell Carcinoma
por: O’Neill, W. Quinn, et al.
Publicado: (2022)

Rac1 as a potential therapeutic target for chemo-radioresistant head and neck squamous cell carcinomas (HNSCC)
por: Skvortsov, S, et al.
Publicado: (2014)

Targeting HPV16 E6-p300 interaction reactivates p53 and inhibits the tumorigenicity of HPV-positive head and neck squamous cell carcinoma
por: Xie, Xiujie, et al.
Publicado: (2013)

Novel Hydrogenosomes in the Microaerophilic Jakobid Stygiella incarcerata
por: Leger, Michelle M., et al.
Publicado: (2016)

Apollon gene silencing induces apoptosis in breast cancer cells through p53 stabilisation and caspase-3 activation
por: Lopergolo, A, et al.
Publicado: (2009)

Gene Duplication Leads to Altered Membrane Topology of a Cytochrome P450 Enzyme in Seed Plants
por: Renault, Hugues, et al.
Publicado: (2017)

Evolution, Expression Patterns, and Distribution of Novel Ribbon Worm Predatory and Defensive Toxins
por: Verdes, Aida, et al.
Publicado: (2022)

The Transposition Rate Has Little Influence on the Plateauing Level of the P-element
por: Kofler, Robert, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_2utaeh1cvo34jv3n1d9q4aoa71