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Persistence of an Oncogenic Papillomavirus Genome Requires cis Elements from the Viral Transcriptional Enhancer

Human papillomavirus (HPV) genomes are replicated and maintained as extrachromosomal plasmids during persistent infection. The viral E2 proteins are thought to promote stable maintenance replication by tethering the viral DNA to host chromatin. However, this has been very difficult to prove genetica...

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Detalles Bibliográficos
Autores principales: Van Doorslaer, Koenraad, Chen, Dan, Chapman, Sandra, Khan, Jameela, McBride, Alison A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698554/
https://www.ncbi.nlm.nih.gov/pubmed/29162712
http://dx.doi.org/10.1128/mBio.01758-17