Oxetane Grafts Installed Site‐Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo

A four‐membered oxygen ring (oxetane) can be readily grafted into native peptides and proteins through site‐selective bis‐alkylation of cysteine residues present as disulfides under mild and biocompatible conditions. The selective installation of the oxetane graft enhances stability and activity, as...

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Detalles Bibliográficos
Autores principales: Martínez‐Sáez, Nuria, Sun, Shuang, Oldrini, Davide, Sormanni, Pietro, Boutureira, Omar, Carboni, Filippo, Compañón, Ismael, Deery, Michael J., Vendruscolo, Michele, Corzana, Francisco, Adamo, Roberto, Bernardes, Gonçalo J. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698723/
https://www.ncbi.nlm.nih.gov/pubmed/28968001
http://dx.doi.org/10.1002/anie.201708847

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698723/
https://www.ncbi.nlm.nih.gov/pubmed/28968001
http://dx.doi.org/10.1002/anie.201708847

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