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Allosteric Tuning of Caspase‐7: A Fragment‐Based Drug Discovery Approach
The caspase family of cysteine proteases are highly sought‐after drug targets owing to their essential roles in apoptosis, proliferation, and inflammation pathways. High‐throughput screening efforts to discover inhibitors have gained little traction. Fragment‐based screening has emerged as a powerfu...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698726/ https://www.ncbi.nlm.nih.gov/pubmed/28940929 http://dx.doi.org/10.1002/anie.201706959 |