Cargando…

Biosynthesis of the Enterotoxic Pyrrolobenzodiazepine Natural Product Tilivalline

The nonribosomal enterotoxin tilivalline was the first naturally occurring pyrrolobenzodiazepine to be linked to disease in the human intestine. Since the producing organism Klebsiella oxytoca is part of the intestinal microbiota and the pyrrolobenzodiazepine causes the pathogenesis of colitis it is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dornisch, Elisabeth, Pletz, Jakob, Glabonjat, Ronald A., Martin, Florian, Lembacher‐Fadum, Christian, Neger, Margit, Högenauer, Christoph, Francesconi, Kevin, Kroutil, Wolfgang, Zangger, Klaus, Breinbauer, Rolf, Zechner, Ellen L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698749/ https://www.ncbi.nlm.nih.gov/pubmed/28977734 http://dx.doi.org/10.1002/anie.201707737

Ejemplares similares

Klebsiella oxytoca enterotoxins tilimycin and tilivalline have distinct host DNA-damaging and microtubule-stabilizing activities
por: Unterhauser, Katrin, et al.
Publicado: (2019)

Tilivalline- and Tilimycin-Independent Effects of Klebsiella oxytoca on Tight Junction-Mediated Intestinal Barrier Impairment
por: Hering, Nina A., et al.
Publicado: (2019)

Enterotoxin tilimycin from gut-resident Klebsiella promotes mutational evolution and antibiotic resistance in mice
por: Kienesberger, Sabine, et al.
Publicado: (2022)

Pd/BIPHEPHOS is an Efficient Catalyst for the Pd‐Catalyzed S‐Allylation of Thiols with High n‐Selectivity
por: Schlatzer, Thomas, et al.
Publicado: (2019)

cAMP Receptor Protein Positively Regulates the Expression of Genes Involved in the Biosynthesis of Klebsiella oxytoca Tilivalline Cytotoxin
por: Rodríguez-Valverde, Diana, et al.
Publicado: (2021)

Efficient Entropy‐Driven Inhibition of Dipeptidyl Peptidase III by Hydroxyethylene Transition‐State Peptidomimetics
por: Ivkovic, Jakov, et al.
Publicado: (2021)

The Enterotoxicity of Clostridium difficile Toxins
por: Sun, Xingmin, et al.
Publicado: (2010)

Bacterial Indole as a Multifunctional Regulator of Klebsiella oxytoca Complex Enterotoxicity
por: Ledala, Nagender, et al.
Publicado: (2022)

The benzodiazepine-like natural product tilivalline is produced by the entomopathogenic bacterium Xenorhabdus eapokensis
por: Wolff, Hendrik, et al.
Publicado: (2018)

Labeling and Natural Post-Translational Modification of Peptides and Proteins via Chemoselective Pd-Catalyzed Prenylation of Cysteine
por: Schlatzer, Thomas, et al.
Publicado: (2019)

Methotrexate enterotoxicity: influence of drug dose and timing in the rat.
por: Pinkerton, C. R., et al.
Publicado: (1984)

Pyrrolobenzodiazepines (PBDs) Do Not Bind to DNA G-Quadruplexes
por: Rahman, Khondaker M., et al.
Publicado: (2014)

Lycopene Maintains Mitochondrial Homeostasis to Counteract the Enterotoxicity of Deoxynivalenol
por: Cai, Zihui, et al.
Publicado: (2023)

Novel pathway of 3-hydroxyanthranilic acid formation in limazepine biosynthesis reveals evolutionary relation between phenazines and pyrrolobenzodiazepines
por: Pavlikova, Magdalena, et al.
Publicado: (2018)

Pyrrolobenzodiazepine Antibody-Drug Conjugates Designed for Stable Thiol Conjugation
por: Christie, R. James, et al.
Publicado: (2017)

Intramolecular Azide to Alkene Cycloadditions for the Construction of Pyrrolobenzodiazepines and Azetidino-Benzodiazepines
por: Hemming, Karl, et al.
Publicado: (2014)

Noncytotoxic Pyrrolobenzodiazepine–Ciprofloxacin Conjugate with Activity against Mycobacterium tuberculosis
por: Picconi, Pietro, et al.
Publicado: (2019)

From Anthramycin to Pyrrolobenzodiazepine (PBD)‐Containing Antibody–Drug Conjugates (ADCs)
por: Mantaj, Julia, et al.
Publicado: (2016)

Enterotoxic effect of stool supernatant of Cryptosporidium-infected calves on human jejunum
por: Guarino, Alfredo, et al.
Publicado: (1994)

A systemic review of the role of enterotoxic Bacteroides fragilis in colorectal cancer
por: Scott, Nancy, et al.
Publicado: (2022)

C=C-Ene-Reductases Reduce the C=N Bond of Oximes
por: Velikogne, Stefan, et al.
Publicado: (2020)

Effect of base sequence on the DNA cross-linking properties of pyrrolobenzodiazepine (PBD) dimers
por: Rahman, Khondaker M., et al.
Publicado: (2011)

Antistaphylococcal activity of DNA-interactive pyrrolobenzodiazepine (PBD) dimers and PBD-biaryl conjugates
por: Rahman, Khondaker M., et al.
Publicado: (2012)

Mutational analysis of the rotavirus NSP4 enterotoxic domain that binds to caveolin-1
por: Ball, Judith M, et al.
Publicado: (2013)

The key role of gut–liver axis in pyrrolizidine alkaloid-induced hepatotoxicity and enterotoxicity
por: He, Yisheng, et al.
Publicado: (2021)

New Concept of the Biosynthesis of 4-Alkyl-L-Proline Precursors of Lincomycin, Hormaomycin, and Pyrrolobenzodiazepines: Could a γ-Glutamyltransferase Cleave the C–C Bond?
por: Jiraskova, Petra, et al.
Publicado: (2016)

Antibacterial activity of silver and zinc nanoparticles against Vibrio cholerae and enterotoxic Escherichia coli
por: Salem, Wesam, et al.
Publicado: (2015)

The Possible Transmission and Potential Enterotoxicity of Bacillus cereus on Lettuce Farms in Five Chinese Provinces
por: Qu, Yang, et al.
Publicado: (2021)

Covalent DNA Binding Is Essential for Gram-Negative Antibacterial Activity of Broad Spectrum Pyrrolobenzodiazepines
por: Picconi, Pietro, et al.
Publicado: (2022)

Supplementation with sesame oil suppresses genotoxicity, hepatotoxicity and enterotoxicity induced by sodium arsenite in rats
por: Akinrinde, Akinleye Stephen, et al.
Publicado: (2023)

Covalent Bonding of Pyrrolobenzodiazepines (PBDs) to Terminal Guanine Residues within Duplex and Hairpin DNA Fragments
por: Mantaj, Julia, et al.
Publicado: (2016)

Potential enterotoxicity and antimicrobial resistance pattern of Aeromonas species isolated from pet turtles and their environment
por: WIMALASENA, S. H. M. P., et al.
Publicado: (2017)

Small-Molecule Inhibitors Targeting Lipolysis in Human Adipocytes
por: Grabner, Gernot F., et al.
Publicado: (2022)

Quantification of Arsenolipids in the Certified Reference Material NMIJ 7405-a (Hijiki) using HPLC/Mass Spectrometry after Chemical Derivatization
por: Glabonjat, Ronald A., et al.
Publicado: (2014)

Interaction of Pyrrolobenzodiazepine (PBD) Ligands with Parallel Intermolecular G-Quadruplex Complex Using Spectroscopy and ESI-MS
por: Raju, Gajjela, et al.
Publicado: (2012)

Quantitation of DNA by nuclease P1 digestion and UPLC-MS/MS to assess binding efficiency of pyrrolobenzodiazepine
por: Ma, Yong, et al.
Publicado: (2020)

Novel Role for Animal Innate Immune Molecules: Enterotoxic Activity of a Snail Egg MACPF-Toxin
por: Giglio, Matías L., et al.
Publicado: (2020)

Synthesis of novel ligands targeting phenazine biosynthesis proteins as a strategy for antibiotic intervention
por: Guttenberger, Nikolaus, et al.
Publicado: (2017)

Correction: Interaction of Pyrrolobenzodiazepine (PBD) Ligands with Parallel Intermolecular G-Quadruplex Complex Using Spectroscopy and ESI-MS
por: Raju, Gajjela, et al.
Publicado: (2012)

Two Regulators of Vibrio parahaemolyticus Play Important Roles in Enterotoxicity by Controlling the Expression of Genes in the Vp-PAI Region
por: Kodama, Toshio, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_e56aef6iqcrkg2jld4ner8f5lj