The role of genomic location and flanking 3′UTR in the generation of functional levels of variant surface glycoprotein in Trypanosoma brucei

Trypanosoma brucei faces relentless immune attack in the mammalian bloodstream, where it is protected by an essential coat of Variant Surface Glycoprotein (VSG) comprising ∼10% total protein. The active VSG gene is in a Pol I‐transcribed telomeric expression site (ES). We investigated factors mediat...

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Detalles Bibliográficos
Autores principales: Ridewood, Sophie, Ooi, Cher‐Pheng, Hall, Belinda, Trenaman, Anna, Wand, Nadina Vasileva, Sioutas, Georgios, Scherwitzl, Iris, Rudenko, Gloria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698767/
https://www.ncbi.nlm.nih.gov/pubmed/28906055
http://dx.doi.org/10.1111/mmi.13838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698767/
https://www.ncbi.nlm.nih.gov/pubmed/28906055
http://dx.doi.org/10.1111/mmi.13838

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