α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration

Genetic variation in a major histocompatibility complex II (MHCII)-encoding gene (HLA-DR) increases risk for Parkinson disease (PD), and the accumulation of MHCII-expressing immune cells in the brain correlates with α-synuclein inclusions. However, the timing of MHCII-cell recruitment with respect t...

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Detalles Bibliográficos
Autores principales: Harms, Ashley S., Delic, Vedad, Thome, Aaron D., Bryant, Nicole, Liu, Zhiyong, Chandra, Sidhanth, Jurkuvenaite, Asta, West, Andrew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698965/
https://www.ncbi.nlm.nih.gov/pubmed/29162163
http://dx.doi.org/10.1186/s40478-017-0494-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698965/
https://www.ncbi.nlm.nih.gov/pubmed/29162163
http://dx.doi.org/10.1186/s40478-017-0494-9

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