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α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration

Genetic variation in a major histocompatibility complex II (MHCII)-encoding gene (HLA-DR) increases risk for Parkinson disease (PD), and the accumulation of MHCII-expressing immune cells in the brain correlates with α-synuclein inclusions. However, the timing of MHCII-cell recruitment with respect t...

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Detalles Bibliográficos
Autores principales:	Harms, Ashley S., Delic, Vedad, Thome, Aaron D., Bryant, Nicole, Liu, Zhiyong, Chandra, Sidhanth, Jurkuvenaite, Asta, West, Andrew B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698965/ https://www.ncbi.nlm.nih.gov/pubmed/29162163 http://dx.doi.org/10.1186/s40478-017-0494-9

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