The margin of internal exposure (MOIE) concept for dermal risk assessment based on oral toxicity data – A case study with caffeine

Route-to-route extrapolation is a common part of human risk assessment. Data from oral animal toxicity studies are commonly used to assess the safety of various but specific human dermal exposure scenarios. Using theoretical examples of various user scenarios, it was concluded that delineation of a...

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Detalles Bibliográficos
Autores principales: Bessems, Jos G.M., Paini, Alicia, Gajewska, Monika, Worth, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699174/
https://www.ncbi.nlm.nih.gov/pubmed/28288858
http://dx.doi.org/10.1016/j.tox.2017.03.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699174/
https://www.ncbi.nlm.nih.gov/pubmed/28288858
http://dx.doi.org/10.1016/j.tox.2017.03.012

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