A computational study of the inhibition mechanisms of P-glycoprotein mediated paclitaxel efflux by kinase inhibitors

BACKGROUND: Drug resistance mediated by P-glycoprotein (P-gp) renders many cancer therapies ineffective. One P-gp substrate is the widely used chemotherapy drug paclitaxel. Co-administration of paclitaxel and another drug that inhibits P-gp may enhance the therapeutic effectiveness of paclitaxel by...

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Detalles Bibliográficos
Autores principales: Bender, Joe, Fang, Jianwen, Simon, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699195/
https://www.ncbi.nlm.nih.gov/pubmed/29162114
http://dx.doi.org/10.1186/s12918-017-0498-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699195/
https://www.ncbi.nlm.nih.gov/pubmed/29162114
http://dx.doi.org/10.1186/s12918-017-0498-x

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