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A computational study of the inhibition mechanisms of P-glycoprotein mediated paclitaxel efflux by kinase inhibitors

BACKGROUND: Drug resistance mediated by P-glycoprotein (P-gp) renders many cancer therapies ineffective. One P-gp substrate is the widely used chemotherapy drug paclitaxel. Co-administration of paclitaxel and another drug that inhibits P-gp may enhance the therapeutic effectiveness of paclitaxel by...

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Detalles Bibliográficos
Autores principales:	Bender, Joe, Fang, Jianwen, Simon, Richard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699195/ https://www.ncbi.nlm.nih.gov/pubmed/29162114 http://dx.doi.org/10.1186/s12918-017-0498-x

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