Deazaguanine derivatives, examples of crosstalk between RNA and DNA modification pathways

Seven-deazapurine modifications were thought to be highly specific of tRNAs, but have now been discovered in DNA of phages and of phylogenetically diverse bacteria, illustrating the plasticity of these modification pathways. The intermediate 7-cyano-7-deazaguanine (preQ(0)) is a shared precursor in...

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Detalles Bibliográficos
Autores principales: Hutinet, Geoffrey, Swarjo, Manal A., de Crécy-Lagard, Valérie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699537/
https://www.ncbi.nlm.nih.gov/pubmed/27937735
http://dx.doi.org/10.1080/15476286.2016.1265200
Descripción
Sumario:Seven-deazapurine modifications were thought to be highly specific of tRNAs, but have now been discovered in DNA of phages and of phylogenetically diverse bacteria, illustrating the plasticity of these modification pathways. The intermediate 7-cyano-7-deazaguanine (preQ(0)) is a shared precursor in the pathways leading to the insetion of 7-deazapurine derivatives in both tRNA and DNA. It is also used as an intermediate in the synthesis of secondary metabolites such as toyocamacin. The presence of 7-deazapurine in DNA is proposed to be a protection mechanism against endonucleases. This makes preQ(0) a metabolite of underappreaciated but central importance.

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