Deazaguanine derivatives, examples of crosstalk between RNA and DNA modification pathways

Seven-deazapurine modifications were thought to be highly specific of tRNAs, but have now been discovered in DNA of phages and of phylogenetically diverse bacteria, illustrating the plasticity of these modification pathways. The intermediate 7-cyano-7-deazaguanine (preQ(0)) is a shared precursor in...

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Autores principales: Hutinet, Geoffrey, Swarjo, Manal A., de Crécy-Lagard, Valérie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699537/
https://www.ncbi.nlm.nih.gov/pubmed/27937735
http://dx.doi.org/10.1080/15476286.2016.1265200
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author Hutinet, Geoffrey
Swarjo, Manal A.
de Crécy-Lagard, Valérie
author_facet Hutinet, Geoffrey
Swarjo, Manal A.
de Crécy-Lagard, Valérie
author_sort Hutinet, Geoffrey
collection PubMed
description Seven-deazapurine modifications were thought to be highly specific of tRNAs, but have now been discovered in DNA of phages and of phylogenetically diverse bacteria, illustrating the plasticity of these modification pathways. The intermediate 7-cyano-7-deazaguanine (preQ(0)) is a shared precursor in the pathways leading to the insetion of 7-deazapurine derivatives in both tRNA and DNA. It is also used as an intermediate in the synthesis of secondary metabolites such as toyocamacin. The presence of 7-deazapurine in DNA is proposed to be a protection mechanism against endonucleases. This makes preQ(0) a metabolite of underappreaciated but central importance.
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spelling pubmed-56995372017-12-01 Deazaguanine derivatives, examples of crosstalk between RNA and DNA modification pathways Hutinet, Geoffrey Swarjo, Manal A. de Crécy-Lagard, Valérie RNA Biol Review Seven-deazapurine modifications were thought to be highly specific of tRNAs, but have now been discovered in DNA of phages and of phylogenetically diverse bacteria, illustrating the plasticity of these modification pathways. The intermediate 7-cyano-7-deazaguanine (preQ(0)) is a shared precursor in the pathways leading to the insetion of 7-deazapurine derivatives in both tRNA and DNA. It is also used as an intermediate in the synthesis of secondary metabolites such as toyocamacin. The presence of 7-deazapurine in DNA is proposed to be a protection mechanism against endonucleases. This makes preQ(0) a metabolite of underappreaciated but central importance. Taylor & Francis 2016-12-12 /pmc/articles/PMC5699537/ /pubmed/27937735 http://dx.doi.org/10.1080/15476286.2016.1265200 Text en © 2017 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Review
Hutinet, Geoffrey
Swarjo, Manal A.
de Crécy-Lagard, Valérie
Deazaguanine derivatives, examples of crosstalk between RNA and DNA modification pathways
title Deazaguanine derivatives, examples of crosstalk between RNA and DNA modification pathways
title_full Deazaguanine derivatives, examples of crosstalk between RNA and DNA modification pathways
title_fullStr Deazaguanine derivatives, examples of crosstalk between RNA and DNA modification pathways
title_full_unstemmed Deazaguanine derivatives, examples of crosstalk between RNA and DNA modification pathways
title_short Deazaguanine derivatives, examples of crosstalk between RNA and DNA modification pathways
title_sort deazaguanine derivatives, examples of crosstalk between rna and dna modification pathways
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699537/
https://www.ncbi.nlm.nih.gov/pubmed/27937735
http://dx.doi.org/10.1080/15476286.2016.1265200
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