Cargando…
A general model for predicting the binding affinity of reversibly and irreversibly dimerized ligands
Empirical data has shown that bivalent inhibitors can bind a given target protein significantly better than their monomeric counterparts. However, predicting the corresponding theoretical fold improvements has been challenging. The current work builds off the reacted-site probability approach to pro...
| Autor principal: | |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699851/ https://www.ncbi.nlm.nih.gov/pubmed/29166663 http://dx.doi.org/10.1371/journal.pone.0188134 |