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Regulatory network structure determines patterns of intermolecular epistasis

Most phenotypes are determined by molecular systems composed of specifically interacting molecules. However, unlike for individual components, little is known about the distributions of mutational effects of molecular systems as a whole. We ask how the distribution of mutational effects of a transcr...

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Detalles Bibliográficos
Autores principales: Lagator, Mato, Sarikas, Srdjan, Acar, Hande, Bollback, Jonathan P, Guet, Călin C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699867/
https://www.ncbi.nlm.nih.gov/pubmed/29130883
http://dx.doi.org/10.7554/eLife.28921