Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91

OBJECTIVE: Besides functioning as an intracellular metabolite, succinate acts as a stress-induced extracellular signal through activation of GPR91 (SUCNR1) for which we lack suitable pharmacological tools. METHODS AND RESULTS: Here we first determined that the cis conformation of the succinate backb...

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Detalles Bibliográficos
Autores principales: Trauelsen, Mette, Rexen Ulven, Elisabeth, Hjorth, Siv A., Brvar, Matjaz, Monaco, Claudia, Frimurer, Thomas M., Schwartz, Thue W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699910/
https://www.ncbi.nlm.nih.gov/pubmed/29157600
http://dx.doi.org/10.1016/j.molmet.2017.09.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699910/
https://www.ncbi.nlm.nih.gov/pubmed/29157600
http://dx.doi.org/10.1016/j.molmet.2017.09.005

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